Leading Edge In This Issue - cell.com.

Researchers have long known that stopping cells escaping from tumours could prevent cancer becoming meta-static, but understanding how tumour cells polarise to form a migratory “leading edge” was an elusive goal, until now.

Scientists have developed an automated method to create 3D ECM-embedded cell spheroids that overcomes these limitations. Spheroid formation time is strongly reduced compared to other methods (minutes rather than days) and it can be applied to a broad range of cell types including cells which naturally do not form cell-cell contacts, endothelial cells, various cancer cell lines, and primary.

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first.

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating.

Cancer cells become mobile by remodelling their cytoskeleton to form migratory structures. This transformation is dominated by actin assembly and disassembly (polymerisation and depolymerisation) in the cytoplasm. Synthesis of filamentous actin produces a force at the leading edge that pushes the plasma membrane forward.

At the leading edge of migrating cells, actin polymerizes and flows backward toward the cell body. This retrograde flow of actin connects to and pulls on integrin cytoplasmic tails via talin. This mechanical force is then transduced to the ECM through integrin heterodimers and drives cell protrusion.

Joan Brugge has been an innovator in cancer research since the beginning of her career, when she isolated the viral and cellular forms of the Src protein as a postdoctoral fellow at the University of Colorado. In this interview, she describes the exciting sequence of events that opened up the field during this time, and discusses why a career in cancer research is still such an inspiring path.

Directed cell migration is critical for embryogenesis and organ development, wound healing and the immune response. Microtubules are dynamic polymers that control directional migration through a number of coordinated processes: microtubules are the tracks for long-distance intracellular transport, crucial for delivery of new membrane components and signalling molecules to the leading edge of a.

This issue of Essays in Biochemistry includes reviews on membrane dynamics, actin dynamics, cell matrix adhesion, microtubules and modelling of cell migration, as well as others, all illustrating the complex nature of the cell migration process. The cover is a compiled 3D image of keratin (green) and actin (red) filament distribution in a migrating keratinocyte.

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The Leading Edge Essay. Management in organizations today are trying to capture both quality and productivity (bottom line results) from their employees, and are spending millions of dollars in time, capital, and human resources. However, without the proper paradigm shift in leadership roles, which must include a new appreciation on the importance of principled centered leadership that.